admin Inflammation, Immune Response, and Dupuytren’s (Excerpt Version)
Article #: Excerpt Article – Inflammation & Immune Response
Title: Inflammation, Immune Response, and Dupuytren’s
Categories: Dupuytren’s Contracture · Inflammation · Immune System · Fibrosis
Keywords: Dupuytren’s contracture, inflammation, immune response, fibroblast activation, cytokines, TGF-β, IL-6, TNF-α, oxidative stress
Slug: inflammation-and-immune-response-dupuytrens
Meta Description: Chronic inflammation fuels Dupuytren’s fibrosis. Discover how calming the immune response may slow fibroblast activation and collagen buildup.
Suggested Alt Text: Immune cells releasing cytokines around fibrotic hand tissue.
Source & Link: Front Immunol. 2021; 12:642319. PubMed Central (Non-CC-BY Excerpt Only)
License: Non-CC-BY (Excerpt Only)
Word Count: ≈ 250
Image Hint: Illustration of immune signaling and fibroblast activation in the palm.
Inflammation, Immune Response, and Dupuytren’s
Inflammation is the body’s natural healing signal, but when it lingers, it can transform repair into scarring. In Dupuytren’s contracture, immune cells such as macrophages and T-cells release cytokines—including TGF-β, IL-6, and TNF-α—that keep fibroblasts active and stimulate abnormal collagen production. This overactivity forms the dense cords that pull fingers inward.
Research suggests that oxidative stress and chronic low-grade inflammation create a self-sustaining feedback loop, much like that seen in other fibrotic or autoimmune-like conditions. These immune triggers may explain why Dupuytren’s sometimes progresses even after surgery or collagenase injection.
Reducing inflammation through balanced nutrition, stress management, and anti-inflammatory therapies may help interrupt this cycle. Future treatments may include immune-modulating biologics designed to calm cytokine activity and normalize fibroblast behavior. Understanding this immune-fibrotic link is key to developing therapies that prevent recurrence and restore healthy hand function.
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Attribution
Excerpt summary adapted from Frontiers in Immunology (2021; 12:642319). For the complete article and reference list, read on PubMed Central once a CC-BY source is verified.
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