
Dupuytren’s: a systems biology disease | Arthritis Research & Therapy
McFarlane RM, Flint MH: Dupuytren’s Disease: Biology and Treatment. 1990, New York: Churchill Livingstone
Rayan GM: Dupuytren disease: anatomy, pathology, presentation, and treatment. J Bone Joint Surg Am. 2007, 89: 189-198. 10.1302/0301-620X.89B2.18161.
Shih B, Bayat A: Scientific understanding and clinical management of Dupuytren’s disease. Nat Rev Rheumatol. 2010, 6: 715-726. 10.1038/nrrheum.2010.180.
Meyerding HW, Black JR, Broders AC: The etiology and pathology of Dupuytren’s contracture. Surg Gynecol Obstetric. 1941, 72: 582-590.
Seemayer TA, Lagacé R, Schürch W, Thelmo WL: The myofibroblast: biologic, pathologic, and theoretical considerations. Pathol Annu. 1980, 15 (Pt 1): 443-470.
Bayat A, McGrouther DA: Management of Dupuytren’s disease – clear advice for an elusive condition. Ann R Coll Surg Engl. 2006, 88: 3-8.
Shaw RB, Chong AKS, Zhang A, Hentz VR, Chang J: Dupuytren’s disease: history, diagnosis, and treatment. Plast Reconstr Surg. 2007, 120: 44e-54e. 10.1097/01.prs.0000278455.63546.03.
Hindocha S, Stanley JK, Watson S, Bayat A: Dupuytren’s diathesis revisited: evaluation of prognostic indicators for risk of disease recurrence. J Hand Surg Am. 2006, 31: 1626-1634. 10.1016/j.jhsa.2006.09.006.
Hayton MJ, Gray ICM: Dupuytren’s contracture: a review. Curr Orthopaed. 2003, 17: 1-7. 10.1054/cuor.2002.0315.
Tse R, Howard J, Wu Y, Gan B: Enhanced Dupuytren’s disease fibroblast populated collagen lattice contraction is independent of endogenous active TGF-beta2. BMC Musculoskelet Disord. 2004, 5: 41-10.1186/1471-2474-5-41.
Drake MJ, Hedlund P, Andersson KE, Brading AF, Hussain I, Fowler C, Landon DN: Morphology, phenotype and ultrastructure of fibroblastic cells from normal and neuropathic human detrusor: Absence of myofibroblast characteristics. J Urol. 2003, 169: 1573-1576. 10.1097/01.ju.0000054928.34777.37.
Moyer KE, Banducci DR, Graham WP, Ehrlich HP: Dupuytren’s disease: physiologic changes in nodule and cord fibroblasts through aging in vitro. in vitro Plast Reconstr Surg. 2002, 110: 187-193. 10.1097/00006534-200207000-00031.
Lubahn JD, Pollard M, Cooney T: Immunohistochemical evidence of nerve growth factor in Dupuytren’s diseased palmar fascia. J Hand Surg Am. 2007, 32: 337-342. 10.1016/j.jhsa.2006.12.011.
Clozel M, Salloukh H: Role of endothelin in fibrosis and antifibrotic potential of bosentan. Ann Med. 2005, 37: 2-12. 10.1080/07853890410018925.
Cordova A, Tripoli M, Corradino B, Napoli P, Moschella F: Dupuytren’s contracture: an update of biomolecular aspects and therapeutic perspectives. J Hand Surg Br. 2005, 30: 557-562. 10.1016/j.jhsb.2005.07.002.
Hnanicek J, Cimburova M, Putova I, Svoboda S, Stritesky J, Kratka K, Sosna B, Horak J: Lack of association of iron metabolism and Dupuytren’s disease. J Eur Acad Dermatol Venereol. 2008, 22: 476-480. 10.1111/j.1468-3083.2007.02506.x.
Kaur S, Forsman M, Ryhänen J, Knuutila S, Larramendy ML: No gene copy number changes in Dupuytren’s contracture by array comparative genomic hybridization. Cancer Genet Cytogenet. 2008, 183: 6-8. 10.1016/j.cancergencyto.2008.01.018.
Rehman S, Salway F, Stanley JK, Ollier WER, Day P, Bayat A: Molecular phenotypic descriptors of Dupuytren’s disease defined using informatics analysis of the transcriptome. J Hand Surg Am. 2008, 33: 359-372. 10.1016/j.jhsa.2007.11.010.
Forsman M, Paakkonen V, Tjaderhane L, Vuoristo J, Kallioinen L, Salo T, Kallioinen M, Ryhanen J: The expression of myoglobin and ROR2 protein in Dupuytren’s disease. J Surg Res. 2008, 146: 271-275. 10.1016/j.jss.2007.06.022.
Johnston P, Chojnowski AJ, Davidson RK, Riley GP, Donell ST, Clark IM: A complete expression profile of matrix-degrading metalloproteinases in Dupuytren’s disease. J Hand Surg Am. 2007, 32: 343-351. 10.1016/j.jhsa.2006.12.010.
Lee LC, Zhang AY, Chong AK, Pham H, Longaker MT, Chang J: Expression of a novel gene, MafB, in Dupuytren’s disease. J Hand Surg Am. 2006, 31: 211-218. 10.1016/j.jhsa.2005.09.007.
O’Gorman D, Wu Y, Seney S, Zhu R, Gan B: Wnt expression is not correlated with beta-catenin dysregulation in Dupuytren’s disease. J Negat Results Biomed. 2006, 5: 13-10.1186/1477-5751-5-13.
Samuel CS, Hewitson TD: Relaxin in cardiovascular and renal disease. Kidney Int. 2006, 69: 1498-1502. 10.1038/sj.ki.5000264.
Maureen DM: Endothelin and endothelin receptor antagonists in systemic rheumatic disease. Arthritis Rheum. 2003, 48: 1190-1199. 10.1002/art.10895.
Pan D, Watson HK, Swigart C, Thomson JG, Honig SC, Narayan D: Microarray gene analysis and expression profiles of Dupuytren’s contracture. Ann Plast Surg. 2003, 50: 618-622. 10.1097/01.SAP.0000069066.35253.B3.
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell. 2000, 100: 57-70. 10.1016/S0092-8674(00)81683-9.
Kholodenko BN, Kiyatkin A, Bruggeman FJ, Sontag E, Westerhoff HV, Hoek JB: Untangling the wires: a strategy to trace functional interactions in signaling and gene networks. Proc Natl Acad Sci USA. 2002, 99: 12841-12846. 10.1073/pnas.192442699.
An G, Hunt CA, Clermont G, Neugebauer E, Vodovotz Y: Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams. J Crit Care. 2007, 22: 169-175. 10.1016/j.jcrc.2006.12.011.
Westerhoff HV, Palsson BO: The evolution of molecular biology into systems biology. Nat Biotechnol. 2004, 22: 1249-1252. 10.1038/nbt1020.
Ahn AC, Tewari M, Poon C-S, Phillips RS: The limits of reductionism in medicine: could systems biology offer an alternative?. PLoS Med. 2006, 3: e208-10.1371/journal.pmed.0030208.
Katagiri F: Attacking complex problems with the power of systems biology. Plant Physiol. 2003, 132: 417-419. 10.1104/pp.103.021774.
Spivey A: Systems biology: the big picture. Environ Health Perspect. 2004, 112: A938-A943.
Jensen PR, Gugten AAvd, Bier M, Heeswijk WCv, Rohwer JM, Molenaar D, Workum Mv, Richard P, Teusink B, Bakker BM, Westerhoff HV: Hierarchies in control. J Biol Systems. 1995, 3: 139-144. 10.1142/S0218339095000137.
Kahn D, Westerhoff HV: Control theory of regulatory cascades. J Theor Biol. 1991, 153: 255-285. 10.1016/S0022-5193(05)80426-6.
Steven Wiley H, Shvartsman SY, Lauffenburger DA: Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 2003, 13: 43-50. 10.1016/S0962-8924(02)00009-0.
Schoeberl B, Gaudet S, Albeck JG, Janes K, Sorger PK, Lauffenburger DA: The apoptotic decision process in TNF alpha-stimulated HT-29 cells: a combined computational and experimental approach. Mol Biol Cell. 2002, 13: 11A-A.
Daran-Lapujade P, Rossell S, van Gulik WM, Luttik MA, de Groot MJ, Slijper M, Heck AJ, Daran JM, de Winde JH, Westerhoff HV, Pronk JT, Bakker BM: The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels. Proc Natl Acad Sci USA. 2007, 104: 15753-15758. 10.1073/pnas.0707476104.
Westerhoff HV: Signalling control strength. J Theor Biol. 2008, 252: 555-567. 10.1016/j.jtbi.2007.11.035.
Hornberg JJ, Bruggeman FJ, Westerhoff HV, Lankelma J: Cancer: a systems biology disease. Biosystems. 2006, 83: 81-90. 10.1016/j.biosystems.2005.05.014.
Boshoff HI, Barry CE, Hornberg J, Bruggeman F, Bakker B, Westerhoff H: Metabolic control analysis to identify optimal drug targets. Prog Drug Res . 2007, 64: 173-189.
Bakker BM, Assmus HE, Bruggeman F, Haanstra JR, Klipp E, Westerhoff H: Network-based selectivity of antiparasitic inhibitors. Mol Biol Rep. 2002, 29: 1-5. 10.1023/A:1020397513646.
Westerhoff HV, Mosekilde E, Noe CR, Clemensen AM: Integrating systems approaches into pharmaceutical sciences. Eur J Pharm Sci. 2008, 35: 1-4. 10.1016/j.ejps.2008.05.011.
Eddy A: Interstitial macrophages as mediators of renal fibrosis. Exp Nephrol. 1995, 3: 76-79.
Almeida I, Faria R, Vita P, Vasconcelos C: Systemic sclerosis refractory disease: From the skin to the heart. Autoimmun Rev. 2011
Hunninghake G: Sarcoidosis: linking inflammation and fibrosis. Am J Med Sci. 1995, 309: 124-133. 10.1097/00000441-199503000-00002.
Selman M, Pardo A, Kaminski N: Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?. PLoS Med. 2008, 5: e62-10.1371/journal.pmed.0050062.
Vaglio A, Salvarani C, Buzio C: Retroperitoneal fibrosis. The Lancet. 2006, 367: 241-251. 10.1016/S0140-6736(06)68035-5.
Hindocha S, John S, Stanley JK, Watson SJ, Bayat A: The heritability of Dupuytren’s disease: familial aggregation and its clinical significance. J Hand Surg Am. 2006, 31: 204-210. 10.1016/j.jhsa.2005.09.018.
Fitzgerald AMP, Kirkpatrick JJR, Naylor IL: Dupuytren’s disease – the way forward?. J Hand Surg Br. 1999, 24: 395-399. 10.1054/jhsb.1999.0207.
Andrew JG, Andrew SM, Ash A, Turner B: An investigation into the role of inflammatory cells in Dupuytren’s disease. J Hand Surg Br. 1991, 16: 267-271. 10.1016/0266-7681(91)90051-O.
Sugden P, Andrew JG, Andrew SM, Freemont AJ: Dermal dendrocytes in Dupuytren’s disease: a link between the skin and pathogenesis?. J Hand Surg Br. 1993, 18: 662-666. 10.1016/0266-7681(93)90030-J.
Baird KS, Alwan WH, Crossan JF, Wojciak B: T-cell-mediated response in Dupuytren’s disease. Lancet. 1993, 341: 1622-1623. 10.1016/0140-6736(93)90760-E.
Gudmundsson KG, Arngrimsson R, Arinbjarnarson S, Olafsson A, Jonsson T: T- and B-lymphocyte subsets in patients with Dupuytren’s disease. Correlations with disease severity. J Hand Surg Br. 1998, 23: 724-727. 10.1016/S0266-7681(98)80083-1.
Gabbiani G, Majno G: Dupuytren’s contracture: fibroblast contraction? An ultrastructural study. Am J Pathol. 1972, 66: 131-146.
Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002, 3: 349-363. 10.1038/nrm809.
Tomasek JJ, Vaughan MB, Haaksma CJ: Cellular structure and biology of Dupuytren’s disease. Hand Clin. 1999, 15: 21-34.
Chang HY, Chi JT, Dudoit S, Bondre C, Van De Rijn M, Botstein D, Brown PO: Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA. 2002, 99: 12877-12882. 10.1073/pnas.162488599.
Kaufman L, Rousseeuw P: Finding Groups in Data: An Introduction to Cluster Analysis (Wiley Series in Probability and Statistics). 2005, Wiley-Interscience
Iwasaki H, Müller H, Stutte HJ, Brennscheidt U: Palmar fibromatosis (Dupuytren’s contracture). Ultrastructural and enzyme histochemical studies of 43 cases. Virchows Arch A Pathol Anat Histopathol. 1984, 405: 41-53. 10.1007/BF00694924.
Kloen P: New insights in the development of Dupuytren’s contracture: a review. Br J Plastic Surg. 1999, 52: 629-635. 10.1054/bjps.1999.3187.
Alioto RJ, Rosier RN, Burton RI, Edward Puzas J: Comparative effects of growth factors on fibroblasts of Dupuytren’s tissue and normal palmar fascia. J Hand Surg Am. 1994, 19: 442-452. 10.1016/0363-5023(94)90059-0.
Badalamente MA, Hurst LC, Grandia SK, Sampson SP: Platelet-derived growth factor in Dupuytren’s disease. J Hand Surg Am. 1992, 17: 317-323. 10.1016/0363-5023(92)90414-K.
Badalamente MA, Sampson SP, Hurst LC, Dowd A, Miyasaka K: The role of transforming growth factor beta in Dupuytren’s disease. J Hand Surg. 1996, 21: 210-215. 10.1016/S0363-5023(96)80102-X.
Bayat A, Alansar A, Hajeer AH, Shah M, Watson JS, Stanley JK, Ferguson MWJ, Ollier WER: Genetic susceptibility in Dupuytren’s disease: lack of association of a novel transforming growth factor beta(2) polymorphism in Dupuytren’s disease. J Hand Surg Br. 2002, 27: 47-49. 10.1054/jhsb.2001.0689.
Vaughan MB, Howard EW, Tomasek JJ: Transforming growth factor-[beta]1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res. 2000, 257: 180-189. 10.1006/excr.2000.4869.
Berndt A, Kosmehl H, Mandel U, Gabler U, Luo X, Celeda D, Zardi L, Katenkamp D: TGF and bFGF synthesis and localization in Dupuytren’s disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin. Histochem J. 1995, 27: 1014-1020.
Lappi DA, Martineau D, Maher PA, Florkiewicz RZ, Buscaglia M, Gonzalez AM, Farris J, Hamer M, Fox R, Baird A: Basic fibroblast growth factor in cells derived from Dupuytren’s contracture: synthesis, presence, and implications for treatment of the disease. J Hand Surg Am. 1992, 17: 324-332. 10.1016/0363-5023(92)90415-L.
Gonzalez AM, Buscaglia M, Fox R, Isacchi A, Sarmientos P, Farris J, Ong M, Martineau D, Lappi DA, Baird A: Basic fibroblast growth factor in Dupuytren’s contracture. Am J Pathol. 1992, 141: 661-671.
Serini G, Gabbiani G: Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res. 1999, 250: 273-283. 10.1006/excr.1999.4543.
Hu FZ, Nystrom A, Ahmed A, Palmquist M, Dopico R, Mossberg I, Gladitz J, Rayner M, Post JC, Ehrlich GD, Preston RA: Mapping of an autosomal dominant gene for Dupuytren’s contracture to chromosome 16q in a Swedish family. Clin Genet. 2005, 68: 424-429. 10.1111/j.1399-0004.2005.00504.x.
Brown JJ, Ollier W, Thomson W, Bayat A: Positive association of HLADRB1* 15 with Dupuytren’s disease in Caucasians. Tissue Antigens. 2008, 72: 166-170. 10.1111/j.1399-0039.2008.01082.x.
Bayat A, Walter J, Lambe H, Watson JS, Stanley JK, Marino M, Ferguson MWJ, Ollier WER: Identification of a novel mitochondrial mutation in Dupuytren’s disease using multiplex DHPLC. Plast Reconstr Surg. 2005, 115: 134-141.
Murrell GA, Francis MJ, Bromley L: Free radicals and Dupuytren’s contracture. Br Med J (Clin Res Ed). 1987, 28: 1373-1375.
Qian A, Meals RA, Rajfer J, Gonzalez-Cadavid NF: Comparison of gene expression profiles between Peyronie’s disease and Dupuytren’s contracture. Urology. 2004, 64: 399-404. 10.1016/j.urology.2004.04.006.
Satish L, Laframboise WA, O’Gorman DB: Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren’s contracture. BMC Med Genomics. 2008, 1: 1-10. 10.1186/1755-8794-1-1.
Ulrich D, Ulrich F, Piatkowski A, Pallua N: Expression of matrix metalloproteinases and their inhibitors in cords and nodules of patients with Dupuytren’s disease. Arch Orthop Trauma Surg. 2009, 129: 1453-1459. 10.1007/s00402-008-0726-3.
Bayat A, Winder C, Stanley J, Day P, Goodacre R: Proteome analysis of dupuytren’s disease differentiating between disease tissue phenotypes (nodule, cord and transverse palmar fascia) and control palmar fascia. J Hand Surg. 2006, 31: 5-
O’Gorman D, Howard JC, Varallo VM, Cadieux P, Bowley E, McLean K, Pak BJ, Gan BS: Identification of protein biomarkers in Dupuytren’s contracture using surface enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Clin Invest Med. 2006, 29: 136-145.
Kraljevic Pavelic S, Sedic M, Hock K, Vucinic S, Jurisic D, Gehrig P, Scott M, Schlapbach R, Cacev T, Kapitanovic S, Pavelic K: An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren’s disease. J Pathol. 2009, 217: 524-533. 10.1002/path.2483.
Rhodes DR, Tomlins SA, Varambally S, Mahavisno V, Barrette T, Kalyana-Sundaram S, Ghosh D, Pandey A, Chinnaiyan AM: Probabilistic model of the human protein-protein interaction network. Nat Biotechnol. 2005, 23: 951-959. 10.1038/nbt1103.
von Mering C, Jensen LJ, Kuhn M, Chaffron S, Doerks T, Krüger B, Snel B, Bork P: STRING 7 – recent developments in the integration and prediction of protein interactions. Nucleic Acids. 2007, 35: D358-D362. 10.1093/nar/gkl825.
ter Kuile BH, Westerhoff HV: Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. FEBS Lett. 2001, 500: 169-171. 10.1016/S0014-5793(01)02613-8.
Lazebnik Y: Can a biologist fix a radio? Or, what I learned while studying apoptosis. Cancer Cell. 2002, 2: 179-182. 10.1016/S1535-6108(02)00133-2.
Emery AE: The muscular dystrophies. The Lancet. 2002, 359: 687-695. 10.1016/S0140-6736(02)07815-7.
Williams R, Mamotte C, Burnett J: Phenylketonuria: an inborn error of 1413 phenylalanine metabolism. Clin Biochem Rev. 2008, 29: 31-41.
Weigelt B, Reis-Filho JS: Histological and molecular types of breast cancer: is there a unifying taxonomy?. Nat Rev Clin Oncol. 2009, 6: 718-730. 10.1038/nrclinonc.2009.166.
Westerhoff HV, Kolodkin A, Conradie R, Wilkinson SJ, Bruggeman FJ, Krab K, van Schuppen JH, Hardin H, Bakker BM, Moné MJ, Rybakova KN, Eijken M, van Leeuwen HJ, Snoep JL: Systems biology towards life in silico: mathematics of the control of living cells. J Math Biol. 2009, 58: 7-34. 10.1007/s00285-008-0160-8.
Au-Yong ITH, Wildin CJ, Dias JJ, Page RE: A review of common practice in Dupuytren surgery. Tech Hand Up Extrem Surg. 2005, 9: 178-187. 10.1097/01.bth.0000186794.90431.a4.
Badalamente MA, Hurst LC, Hentz VR: Collagen as a clinical target: nonoperative treatment of Dupuytren’s disease. J Hand Surg. 2002, 27: 788-798. 10.1053/jhsu.2002.35299.
Gilpin D, Coleman S, Hall S, Houston A, Karrasch J, Jones N: Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren’s disease. J Hand Surg Am. 2010, 35: 2027-2038. 10.1016/j.jhsa.2010.08.007.
Snoep JL, Bruggeman F, Olivier BG, Westerhoff HV: Towards building the silicon cell: a modular approach. Biosystems. 2006, 83: 207-216. 10.1016/j.biosystems.2005.07.006.
Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, Arkin AP, Bornstein BJ, Bray D, Cornish-Bowden A, Cuellar AA, Dronov S, Gilles ED, Ginkel M, Gor V, Goryanin II, Hedley WJ, Hodgman TC, Hofmeyr JH, Hunter PJ, Juty NS, Kasberger JL, Kremling A, Kummer U, Le Novère N, Loew LM, Lucio D, Mendes P, Minch E, Mjolsness ED, et al: The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics. 2003, 19: 524-531. 10.1093/bioinformatics/btg015.
Cuellar AA, Lloyd CM, Nielsen PF, Bullivant DP, Nickerson DP, Hunter PJ: An overview of CellML 1.1, a biological model description language. Simulation. 2003, 79: 740-747. 10.1177/0037549703040939.
Jeong E, Nagasaki M, Saito A, Miyano S: Cell system ontology: representation for modeling, visualizing, and simulating biological pathways. In Silico Biol. 2007, 7: 623-638.
Demir E, Cary MP, Paley S, Fukuda K, Lemer C, Vastrik I, Wu G, D’Eustachio P, Schaefer C, Luciano J, Schacherer F, Martinez-Flores I, Hu Z, Jimenez-Jacinto V, Joshi-Tope G, Kandasamy K, Lopez-Fuentes AC, Mi H, Pichler E, Rodchenkov I, Splendiani A, Tkachev S, Zucker J, Gopinath G, Rajasimha H, Ramakrishnan R, Shah I, Syed M, Anwar N, Babur O, et al: The BioPAX community standard for pathway data sharing. Nat Biotechnol. 2010, 28: 935-942. 10.1038/nbt.1666.
Le Novère N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, Demir E, Wegner K, Aladjem MI, Wimalaratne SM, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman TC, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, et al: The Systems Biology Graphical Notation. Nat Biotechnol. 2009, 27: 735-741. 10.1038/nbt.1558.
Hoops S, Sahle S, Gauges R, Lee C, Pahle J, Simus N, Singhal M, Xu L, Mendes P, Kummer U: COPASI – a COmplex PAthway SImulator. Bioinformatics. 2006, 22: 3067-3074. 10.1093/bioinformatics/btl485.
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T: Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003, 13: 2498-2504. 10.1101/gr.1239303.
Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF, Inflamm and Host Response to Injury Large Scale Collab. Res. Program: A network-based analysis of systemic inflammation in humans. Nature. 2005, 437: 1032-1037. 10.1038/nature03985.
Olivier BG, Snoep JL: Web-based kinetic modelling using JWS Online. Bioinformatics. 2004, 20: 2143-2144. 10.1093/bioinformatics/bth200.
Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M: BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Res. 2006, 34: D689-D691. 10.1093/nar/gkj092.
Le Novère N, Finney A, Hucka M, Bhalla US, Campagne F, Collado-Vides J, Crampin EJ, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL: Minimum information requested in the annotation of biochemical models (MIRIAM). Nat Biotechnol. 2005, 23: 1509-1515. 10.1038/nbt1156.
Humphries M, Reynolds A: Cell-to-cell contact and extracellular matrix. Curr Opin Cell Biol. 2009, 21: 613-615. 10.1016/j.ceb.2009.09.001.
van der Greef J, Hankemeier T, McBurney RN: Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?. Pharmacogenomics. 2006, 7: 1087-1094. 10.2217/14622416.7.7.1087.
Kim YS, Maruvada P, Milner JA: Metabolomics in biomarker discovery: future uses for cancer prevention. Future Oncol. 2008, 4: 93-102. 10.2217/14796694.4.1.93.
Hollywood K, Brison DR, Goodacre R: Metabolomics: current technologies and future trends. Proteomics. 2006, 6: 4716-4723. 10.1002/pmic.200600106.